Therapeutic Antibody Discovery yabo体育yabo体育首页s
Blockbusters (such as Humira, Enbrel and Herceptin) achieved huge success because of proven clinical efficacy, strong market demand, thourough IP protection and market penetration strategies. The strict R&D standards are the cornerstones of blockbuster.
In the past 10 years, GenScript has been sticking to the "blockbuster" standards to manage, research and deliver every therapeutic programs. GenScript delivers humanized, human and bispecific antibody leads with good biological efficacy, safety & manufacturability in 12-15 months, as your one-stop solution from Targets to Therapeutic Antibody Candidates.
|Functional Ab Lead||Antibody Lead
|Functional Optimized Lead with good manufacturability||Antibody Lead
|Optimized Lead with good biological efficacy, safety & manufacturability||In Vivo Efficacy, Exploratory PK & Toxicity Studies|
- Murine Hybridoma Technology & Human Naïve Library Technology
- >400 therapeutic antibody discovery projects delivered
- Successful cases in IND
- Single transmembrane targets, such as immune checkpoints
- Multiple transmembrane targets, such as GPCR
- Delivered Functional Humanized/Human Antibody Lead with Good Developability
- All-in-one supplier
- Save at least 5 months for antibody discovery program
- Innovative SMAB Bispecific Antibody
|Discovery yabo体育yabo体育首页s||Testing Options||Deliverables||Timeline|
|M1: Antibody Lead Generation||Bioassays||
||Biochemical & Biophysical Assays
|M2: Antibody Lead Optimization||In Vivo Efficacy, Exploratory PK & Toxicity Studies||
- 12 antibody leads recognizing 2 distinct epitopes were obtained.
- 2 antibody leads with different epitopes were moved forward to lead optimization.
- 2 antibody leads were humanized and then tested by functional assay.
- Their developabilities were evaluated by both experimental & predicted approaches.
|Ligand||Analyte||ka (1/Ms)||kd (1/s)||KD (M)||Rmax (RU)||Chi² (RU²)|
|Humanized Ab Lead||7.05E±05||1.00E-05||1.42E-11||38.2||5.28E-02|
|Thermostability (Tm)||>60 °C (by DSC)|
|Extra Cys||No hotspot predicted, confirmed by Mass Spec|
|Oxidation||2 hot spots predicted and confirmed by Mass Spec,
Not impact binding by Biacore & on stability by SEC under forced oxidation
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